Synthesis and characterization of bimetallic complexes of divalent ions with inhibitory effect of herpes simplex virus replication

Abstract

Herpes simplex virus (HSV) are pathogens that infect men and animals causing a wide variety of disease states, there are two types HSV-1 and HSV-2. Worldwide, more than 3,700 million people have HSV-1 infection and about 417 million have HSV-2. HSV is well distributed worldwide, with more than 23 million new cases per year. In general, current medical treatments for HSV infection are focused on episodic treatment with topical agents or oral antiviral agents, based on acyclovir, cidofovir and foscarnet, which have considerable adverse effects, without having to date A definitive cure Treatments for HSV infections in humans that consist of chemical compositions based on metal chelating complexes have been reported. In the present study, a methodological strategy was developed to synthesize at a laboratory level a bimetallic complex of EDTA and divalent ions Zn²⁺ and Cu²⁺ respectively. The synthesized molecule of ZnCu[EDTA].6H2O was characterized physicochemically and by IR spectroscopy and it was concluded that it can be used in the treatment of HSV infection since the controlled release of metal ions has the ability to inhibit HSV replication.